.jpg "bIO-Optic 220 connected to RamanRxn probe, aiming up and right, top view")
Raman spectroscopy - advanced optical analysis technology
Boost plant safety, ensure product quality, and optimize operations. Raman spectroscopy measures the composition and molecular structure of your samples from lab-to-process in real time.
Specs at a glance
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Sampling probe compatibility
Raman Rxn-10 probe
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Wetted materials
Body: 316L stainless steel
Window: Proprietary material, optimized for bioprocesses
Process connection: PG13.5
Surface finish: Ra 15 with electropolish
Adhesive: USP Class VI and ISO 10993 compatible -
Sterilization method
Autoclave
Field of application
Raman bIO-Optics are versatile immersion optics used in conjunction with the Rxn-10 probehead and compatible with standard bioreactor ports. The fixed focus design provides long-term measurement stability along with superior signal performance, essential for transferable, high performance Raman-based bioprocess analysis. Available in industry standard lengths, Raman bIO-Optics are ideally suited for both glass and plastic benchtop bioreactor/fermenter applications requiring headplate entry.
Cell culture: glucose, lactate, glutamine, amino acids, cell density, titer
Fermentation: glycerol, methanol, ethanol, sorbitol, biomass
Downstream: aggregation, protein crystallization, formula stability, product CQA, protein concentration, buffer excipients
Benefits
Immersion optics for multi-component bioprocess measurement
Compatible with standard bioreactor ports
Fixed-focus design
Available in 12 mm diameter with Pg 13.5 threaded connector
120, 220, 320, or 420 mm lengths
Autoclavable
Extended selection
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High-end products
- Highly functional and convenient
Technical excellence
Simplicity
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Standard products
- Reliable, robust and low-maintenance
Technical excellence
Simplicity
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Specialized products
- Designed for demanding applications
Technical excellence
Simplicity
Variable
| FLEX selections | Technical excellence | Simplicity |
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Fundamental selection Meet your basic measurement needs |
Technical excellence
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Simplicity
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Lean selection Handle your core processes easily |
Technical excellence
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Simplicity
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Extended selection Optimize your processes with innovative technologies |
Technical excellence
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Simplicity
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Xpert selection Master your most challenging applications |
Technical excellence
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Simplicity
Variable |
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Success stories
19 documents
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Technical Information (TI)
Accessory optics for the Rxn-10 probe Technical Information
System design and specifications for Rxn-10 probe optics:
Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL),
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/2022Language:
English
Version:
31/05/2023
File size:
467.9 KB
File name:
TI01635CEN_0322.pdf
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Technical Information (TI)
Rxn-10 Raman spectroscopic probe Technical Information
System design and specifications for the Raman Rxn-10 probe
EN 08/09/202513/11/202431/05/202313/09/202208/09/2021Language:
English
Version:
08/09/2025
File size:
949 KB
File name:
TI01629CEN_0525.pdf
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Operating Instruction (BA)
Accessory optics for the Rxn-10 probe Operating Instructions
Commissioning, operation, and maintenance details
for Rxn-10 probe optics: Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL)
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/202214/09/2021Language:
English
Version:
31/05/2023
File size:
1.8 MB
File name:
BA02171CEN_0322.pdf
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Operating Instruction (BA)
Rxn-10 Raman spectroscopic probe Operating Instructions
Commissioning, operation, and maintenance details
for the Raman Rxn-10 probeEN 08/09/202502/12/202431/05/202313/09/202208/09/2021Language:
English
Version:
08/09/2025
File size:
1.8 MB
File name:
BA02160CEN_0525.pdf
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Short Instruction (KA)
Rxn-10 Raman spectroscopic probe Brief Operating Instructions
Quick start guide for the Raman Rxn-10 probe
EN 02/12/202431/05/202313/09/202208/09/2021Language:
English
Version:
02/12/2024
File size:
1.6 MB
File name:
KA01546CEN_0424.pdf
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Short Instruction (KA)
Accessory optics for the Rxn-10 probe Brief Operating Instructions
Quickstart guide for Rxn-10 probe optics:
Raman immersion optics (KIO1),
non-contact optics (KNCO1), bIO-Optics (KLBIO1),
bio multi optics (KRBMO), bio sleeves (KRBSL),
and Raman optic system for single use (KRSU1)EN 31/05/202303/08/202214/09/2021Language:
English
Version:
31/05/2023
File size:
1 MB
File name:
KA01551CEN_0322.pdf
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PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences
A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).Language:
English
Version:
19/04/2022
File size:
1.1 MB
File name:
PU01447CEN_0222.pdf
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PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles
A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.Language:
English
Version:
26/06/2025
File size:
363.4 KB
File name:
PU01611CEN_0125.pdf
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PU (Publication)
Raman-Anwendungsleitfaden für die Life-Sciences-Industrie
Ein Leitfaden zu unseren Anwendungshinweisen zur
Raman-Spektroskopie für die Life-Science-Industrie
(Raman Rxn2-Analysator, Raman Rxn4-Analysator,
Rxn-10-Sonde, Rxn-20-Sonde, Rxn-45-Sonde,
Rxn-46-Sonde und Zubehör für Sondenoptiken
(blO-Optic, Raman- Single Use-Optiksystem
/ SUB, Immersionsoptik, berührungslose Optik)Language:
German
Version:
24/09/2025
File size:
1.4 MB
File name:
PU01447CDE_0222_Raman-Anwendungsleitfaden_LSI_web.pdf
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PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析
ライフサイエンス産業向けラマン分光法アプリケーションノート（
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ（bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック）。Language:
Japanese
Version:
02/08/2024
File size:
1.4 MB
File name:
PU01447CJA_0222_Raman_App_Guide_for_LifeScience.pdf
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