Specs at a glance
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Laser wavelength
Base model: 532 nm, 785 nm, 1000 nm
Enclosure configuration: 532 nm, 785 nm, 1000 nm
Hybrid: 785 nm -
Spectral coverage
Base Model and Enclosure configuration
532 nm: 100-4350* cm-1
785 nm: 100-3425* cm-1
1000 nm: 200-2400 cm-1
Hybrid 785 nm: 150-1890** cm-1
*Low signal-to-noise ratio at <150 cm-1
**Low signal-to-noise ratio at <175 cm-1
Field of application
The Raman Rxn4 analyzer powered by Kaiser Raman technology is the optimal choice for manufacturing or process environments. Raman Rxn4 provides high-resolution performance for in situ, real-time measurement and control. It features unique self-monitoring, diagnostics, and self-calibration to ensure the validity of each measurement. Stackable in a standard 19" rack, the Raman Rxn4 saves valuable space on the production floor. It is also offered with an optional stainless steel NEMA 4X enclosure.
Chemical: reaction monitoring, blending, catalysis investigations
Polymer: polymerization reaction monitoring, extrusion monitoring, polymer blending
Pharmaceutical: API reaction monitoring, crystallization, polymorph
Biopharmaceutical: bioprocess monitoring and control, PAT/QbD applications, cell culture, fermentation, downstream operations, cGLP/cGMP compatible
Food & Beverage: Mapping of meats and fish, fermentation, reaction monitoring
Oil & Gas: LNG, refining, energy measurements
Benefits
Robust, reliable, and highly accurate
Easy installation and minimal maintenance/downtime
24/7 inline, online, or at-line process measurement and monitoring
Unified internal construction enables straightforward model transfer to support redundant analyzer systems
Intuitive, fully embedded Raman RunTime control software via touchscreen or remote interface
Scale-up, scale-out, and cGMP/pilot-plant compatible
Suitable for outputs into hazardous area/classified environments
Extended selection
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High-end products
- Highly functional and convenient
Technical excellence
Simplicity
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Standard products
- Reliable, robust and low-maintenance
Technical excellence
Simplicity
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Specialized products
- Designed for demanding applications
Technical excellence
Simplicity
Variable
| FLEX selections | Technical excellence | Simplicity |
|---|---|---|
Fundamental selection Meet your basic measurement needs |
Technical excellence
|
Simplicity
|
Lean selection Handle your core processes easily |
Technical excellence
|
Simplicity
|
Extended selection Optimize your processes with innovative technologies |
Technical excellence
|
Simplicity
|
Xpert selection Master your most challenging applications |
Technical excellence
|
Simplicity
Variable |
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Technical Information (TI)
Raman Rxn4 Technical Information
System design and specifications for the Raman Rxn4 analyzer -
powered by Kaiser Raman technologyEN 21/11/202301/09/202331/12/2020Language:
English
Version:
21/11/2023
File size:
1.1 MB
File name:
TI01645CEN_0323.pdf
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Technical Information (TI)
Raman data library 2.1 Technical Information
System information and specifications for the Raman data library 2.1
EN 08/09/2025Language:
English
Version:
08/09/2025
File size:
191.3 KB
File name:
TI01869CEN_0125.pdf
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Operating Instruction (BA)
Raman RunTime v6.6 Operating Instructions
Commissioning, operation, and maintenance details
for Raman RunTime v6.6 softwareEN 27/03/202516/11/202316/11/202230/06/202231/12/2020Language:
English
Version:
27/03/2025
File size:
6.8 MB
File name:
BA02180CEN_0525.pdf
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Operating Instruction (BA)
Raman data library 2.1 Administrator Operating Instructions
Instructions for administration of Raman data library 2.1 software
EN 08/09/2025Language:
English
Version:
08/09/2025
File size:
1.2 MB
File name:
BA02564CEN_0125.pdf
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Operating Instruction (BA)
Raman Rxn4 Operating Instructions
Commissioning, operation, and maintenance details
for the Raman Rxn4 analyzer - powered by Kaiser Raman technologyEN 27/03/202421/11/202301/08/202331/12/2020Language:
English
Version:
27/03/2024
File size:
6.6 MB
File name:
BA02178CEN_0424.pdf
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Operating Instruction (BA)
Raman data library 2.1 User Operating Instructions
Instructions for use of Raman data library 2.1
EN 08/09/2025Language:
English
Version:
08/09/2025
File size:
4.5 MB
File name:
BA02563CEN_0125.pdf
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Operating Instruction (BA)
LNG parameters & calibration Operating Instructions
A complete overview of the LNG parameters and calibration for the
Raman analyzerEN 21/08/2024Language:
English
Version:
21/08/2024
File size:
865.4 KB
File name:
BA02371CEN_0124.pdf
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Short Instruction (KA)
Raman data library Brief Operating Instructions
Brief instructions and start-up instructions for Raman data library
softwareEN 13/08/2024Language:
English
Version:
13/08/2024
File size:
411.2 KB
File name:
KA01717CEN_0124.pdf
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Short Instruction (KA)
Raman Rxn4 Brief Operating Instructions
Quick start guide for the Raman Rxn4 analyzer -
powered by Kaiser Raman technologyEN 21/11/202331/12/2020Language:
English
Version:
21/11/2023
File size:
2.5 MB
File name:
KA01553CEN_0222.pdf
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Installation Instructions (EA)
LNG analyzer performance verification kit Installation Instructions
Instructions for use of the LNG analyzer performance verification kit
EN 30/03/2023Language:
English
Version:
30/03/2023
File size:
442.7 KB
File name:
EA01470CEN_0123.pdf
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Ex Safety Instruction (XA)
Raman Rxn4 Safety Instructions
Hazardous area certifications and installation instructions
for the Raman Rxn4 analyzer - powered by Kaiser Raman technologyEN 16/01/202507/12/202329/11/202231/12/2020Language:
English
Version:
16/01/2025
File size:
1.2 MB
File name:
XA02745CEN_0424.pdf
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PU (Publication)
Advanced process and product control in fermentations - Raman spectroscopy for composition analysis in a lab or process
An overview of Raman spectroscopy analyzer systems (including the
Raman Rxn2 analyzer, Raman Rxn4 analyzer, Rxn-10 probe, and Rxn-45
probe), powered by Kaiser Raman technology, for fermentation
compositional analysis in a lab or process applicable to biotechnology
in the food & beverage industry.Language:
English
Version:
03/03/2022
File size:
603 KB
File name:
PU01457CEN_0122.pdf
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PU (Publication)
Endress+Hauser - your one-source Life Sciences technology partner
Graphic highlighting why Endress+Hauser is trusted by the
world's top biopharmaceutical manufacturers for its Life
Sciences expertise and reliable inline, real-time measurement
technologies like Raman spectroscopy systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology (Liquiline CM44P, CM442 and
OUSAF44, OUSBT66 and Memosens CPS61E, CLS82E, COS81E,
CLS82E).Language:
English
Version:
27/06/2024
File size:
1.9 MB
File name:
PU01585CEN_0124.pdf
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PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
Czech
Version:
06/09/2024
File size:
381.4 KB
File name:
PU01584CEN_0124_cz_view.pdf
-
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PU (Publication)
Raman application guide for the life science industry - Trusted composition analysis for the life sciences
A guide to our Raman spectroscopy application notes for the
Life Science industry (featuring the Raman Rxn2 analyzer,
Raman Rxn4 analyzer, Rxn-10 probe, Rxn-20 probe, Rxn-45 probe,
Rxn-46 probe, and probe accessory optics (bIO-Optic, Raman single
use optic system / SUB, immersion optic, non-contact optic).Language:
English
Version:
19/04/2022
File size:
1.1 MB
File name:
PU01447CEN_0222.pdf
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-
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PU (Publication)
Biopharma 4.0 model graphic
Graphic illustrating the core elements of Biopharma 4.0 including
product lifecycle stages, role of PAT/QbD, and 12 key advanced
technologies for scientists and process engineers in the Life
Sciences, applicable to Raman spectroscopy systems (Raman
Rxn2, Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and
sleeve, flow cell and flow bench, Raman optic system for single
use, and Raman calibration & verification kits).Language:
English
Version:
22/05/2025
File size:
481.6 KB
File name:
PU01614CEN_0125.pdf
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PU (Publication)
Top must-read Biopharma 4.0 articles - Stay informed about the latest research embracing Biopharma 4.0 principles
A list of published technical articles related to Biopharma 4.0
topics with recommendations from Life Science industry experts
at Endress+Hauser.Language:
English
Version:
26/06/2025
File size:
363.4 KB
File name:
PU01611CEN_0125.pdf
-
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PU (Publication)
Kaiser Raman technology and Sartorius BioPAT Spectro® collaboration Q&A - Scalable, real-time bioprocess monitoring solutions
A Q&A about how our Raman spectroscopy analyzer systems
(including the Raman Rxn2 analyzer, Raman Rxn4 analyzer,
and Rxn-46 probe), powered by Kaiser Raman technology, integrates
with the Sartorius BioPAT Spectro platform (Ambr and biostat STR) for
high throughput and single use (SUB) bioprocessingin the
biopharmaceutical life science industry.Language:
English
Version:
08/12/2021
File size:
943.7 KB
File name:
PU01446CEN_0121.pdf
-
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PU (Publication)
Endress+Hauser - ライフサイエンス技術のワンストップパートナー
Endress+Hauserが、ライフサイエンス分野の専門知識と、ラマン分
光システム(Raman Rxn2、Raman Rxn4、Rxn-10、Rxn-45、Rxn-46、
バイオマルチオプティックおよびスリーブ、フローフィル、フロー
ベンチ、シングルユース用Ramanオプティックシステム)や水質分
析センサ技術(Liquiline CM44P、CM442、OUSAF44、OUSBT66、
Memosens CPS61E、CLS82E、COS81E、CLS82E)などの信頼性の高い
インラインおよびリアルタイム測定技術によって、世界トップクラ
スのバイオ医薬品メーカーから信頼されている理由を強調したグラ
フィック。Language:
Japanese
Version:
04/10/2024
File size:
2.5 MB
File name:
PU01585CJA_0124_Graphic_EH biopharma trust.pdf
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PU (Publication)
石油・ガスおよび化学産業向け ラマン分光計アプリケーションガイド - ガスストリームおよびLNGの組成分析
化学産業および石油・ガス産業におけるガスストリームおよび LNG
の組成分析用(Raman Rxn4 アナライザー、Raman Rxn5 アナライザ
ー、Raman Rxn-30 プローブ、Raman Rxn-41 プローブを含む)、
Kaiser Raman テクノロジーによるラマン分光アナライザーおよび
プローブ製品ラインアップのご案内です。Language:
Japanese
Version:
13/05/2024
File size:
4.2 MB
File name:
PU01445CJA_0121_RamanAnalyzer_AppGuide_OilGas_ChemInd.pdf
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PU (Publication)
ライフサイエンスにおけるラボからプロセスまでの監視と制御 バイオプロセスの物理的・化学的特性の信頼性の高い測定
この製品リストは、ライフサイエンス業界におけるバイオプロセス
用途向けに、光学分析および液体分析の両方から提供される分析機
器をまとめたものです。含まれる製品には、Raman Rxn2アナライザ
、Raman Rxn4アナライザ、Rxn-10プローブ、バイオマルチオプティ
ックおよびバイオスリーブ、ラマンフローアセンブリ、Rxn-45プロ
ーブ、Rxn-46プローブ、シングルユース向けラマンオプティックシ
ステム、Memosens CPS61E、Memosens COS81E、OUSBT66、Memosens
CPS77E、Memosens CLS82E、OUSAF44、Memosens CPS11E、Memosens
CLS16E、TOCアナライザーCA79、Liquiline変換器プラットフォーム
、およびMemobaseソフトウェアが含まれています。Language:
Japanese
Version:
24/08/2025
File size:
1.2 MB
File name:
PU01484CJA_0224_Lab-to-Process Control in Life Sciences.pdf
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-
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PU (Publication)
Biopharma 4.0 model graphic (full version)
Expanded version of a graphic illustrating the core elements of
Biopharma 4.0 including product lifecycle stages, role of
PAT/QbD, and 12 key advanced technologies for scientists and
process engineers in the Life Sciences, applicable to Raman
spectroscopy systems (Raman Rxn2, Raman Rxn4, Rxn-10,
Rxn-45, Rxn-46, bio multi optic and sleeve, flow cell and flow
bench, Raman optic system for single use, and Raman calibration
& verification kits).Language:
English
Version:
22/05/2025
File size:
29.1 MB
File name:
PU01613CEN_0125.pdf
-
-
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PU (Publication)
Raman data library -- Faster time to market with increased insight, productivity, and data integrity
This document provides insight into the core and cGxP
features of Raman data library (data organization, visualization,
user management, and univariate analysis for Raman Rxn2
and Raman Rxn4 analyzers), while also addressing common
questions regarding the software's functionalities.Language:
English
Version:
21/06/2024
File size:
3.3 MB
File name:
PU01583CEN_0124.pdf
-
-
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PU (Publication)
Energiewende Unsere Gasanalysegeräte sind bereit
Ein Überblick über die Energiewende
und die Bedeutung der Gasanalyse.Language:
German
Version:
04/06/2025
File size:
2.3 MB
File name:
PU01458C11DE_0224_web.pdf
-
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PU (Publication)
Enhancing Raman data integrity and compliance based on ALCOA+ principles
A publication explaining how Raman data library software can be used
in cGxP environments for improved process control and regulatory
compliance.Language:
English
Version:
03/09/2025
File size:
16.6 MB
File name:
PU01618CEN_0125.pdf
-
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PU (Publication)
ライフサイエンス産業向けのラマンアプリケーションガイド -ライフサイエンスのための信頼できる組成分析
ライフサイエンス産業向けラマン分光法アプリケーションノート(
ラマンRxn2アナライザー、ラマンRxn4アナライザー、Rxn-10プロー
ブ、Rxn-20プローブ、Rxn-45プローブ、Rxn-46プローブ、プローブ
オプティックアクセサリ(bIOオプティック、シングルユース向け
ラマンオプティックシステム/SUB、浸漬オプティック、非接触オプ
ティック)。Language:
Japanese
Version:
02/08/2024
File size:
1.4 MB
File name:
PU01447CJA_0222_Raman_App_Guide_for_LifeScience.pdf
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PU (Publication)
Raman calibration and verification kits - Everything needed to calibrate and verify your Raman analyzer system for lab-to-process scalability
An overview of the Raman calibration and verification kits for
the bio multi optic / single use optic and the Raman flow assembly
(includes the flow bench and flow cell). These kits are to be used in
conjunction with the Rxn-10 probe and Raman Rxn2 / Rxn4 analyzer
for upstream and downstream bioprocessing (powered by Kaiser
Raman technology).Language:
English
Version:
13/12/2023
File size:
2.1 MB
File name:
PU01518CEN_0223.pdf
-
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PU (Publication)
Raman Rxn4 analyzer - LNG custody transfer analyzer
An overview brochure about the Raman Rxn4 analyzer,
a Raman spectroscopy analyzer powered by Kaiser Raman
technology for LNG custody transfer in the Oil & Gas industry.Language:
English
Version:
20/01/2022
File size:
492.1 KB
File name:
PU01451CEN_0122.pdf
-
-
-
PU (Publication)
Prioritize scalability for an efficient biopharmaceutical product development lifecycle
This technical paper studies the importance of scalability as a
competitive advantage in bioprocessing in the Life Science industry,
and Endress+Hauser's scalable Raman systems (Raman Rxn2,
Raman Rxn4, Rxn-10, Rxn-45, Rxn-46, bio multi optic and sleeve,
flow cell and flow bench, Raman optic system for single use) and
liquid analysis sensor technology and Liquid Analysis portfolio
(Liquiline CM44P, CM442 and OUSAF44, OUSBT66 and
Memosens CPS61E, CLS82E, COS81E, CLS82E).Language:
English
Version:
27/06/2024
File size:
753.7 KB
File name:
PU01584CEN_0124.pdf
-
-
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PU (Publication)
The Biopharma 4.0 glossary - Test your Biopharma 4.0 IQ
A list of definitions and sources for frequently used terms and
abbreviations in the biopharmaceutical industry related to
Biopharma 4.0.Language:
English
Version:
17/06/2025
File size:
445 KB
File name:
PU01610CEN_0125.pdf
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